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Submit ReviewValerenic acid
说明： Positive allosteric modulator of GABAA receptors
化学名： (2E)-3-[(4S,7R,7aR)-2,4,5,6,7,7a-Hexadydro-3,7-dimethyl-1H-inden-4-yl]-2-methyl-2-propenoic acid
纯度： ≥99% (HPLC)
生物活性 for Valerenic acid
Valerenic acid is a positive allosteric modulator of GABAA receptors that displays preference for receptors containing β2 or β3 subunits. Directly activates the receptor and blocks the channel at high concentrations. Displays sedative, anticonvulsant and anxiolytic activity in vivo. Also acts as a partial agonist of 5-HT5A receptors.
技术数据 for Valerenic acid
| 分子量 | 234.33 |
| 公式 | C15H22O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 3569-10-6 |
| PubChem ID | 6440940 |
| InChI Key | FEBNTWHYQKGEIQ-SUKRRCERSA-N |
| Smiles | C[C@@H]2CC[C@@H](/C=C(C(O)=O)\C)C1=C(C)CC[C@@]12[H] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Valerenic acid
参考文献 for Valerenic acid
参考文献是支持产品生物活性的出版物。
Dietz et al (2005) Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res.Mol.Brain Res. 138 191 PMID: 15921820
Benke et al (2008) GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology 56 174 PMID: 18602406
Khom et al (2007) Valerenic acid potentiates and inhibits GABAA receptors: molecular mechanism and subunit specificity. Neuropharmacol. 53 178 PMID: 17585957
Khom et al (2016) Analysis of β-subunit-dependent GABAA receptor modulation and behavioral effects of valerenic acid derivatives. J.Pharmacol.Exp.Ther. 357 580 PMID: 27190170
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关键词: Valerenic acid, Valerenic acid supplier, Positive, allosteric, modulators, GABAA, receptors, Receptors, PAM, 3048, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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