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Submit ReviewVeratridine
说明： Voltage-gated Na+ channel opener
化学名： 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol
纯度： ≥98% (HPLC)
生物活性 for Veratridine
Veratridine is a voltage-gated Na+ channel opener; increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Steroid-derived alkaloid neurotoxin. Increases membrane Na+ permeability and depolarizes excitable tissues.
技术数据 for Veratridine
| 分子量 | 673.79 |
| 公式 | C36H51NO11 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 71-62-5 |
| PubChem ID | 6280 |
| InChI Key | FVECELJHCSPHKY-YFUMOZOISA-N |
| Smiles | O=C(C8=CC=C(OC)C(OC)=C8)O[C@H]1CC[C@@]2(C)[C@@]3([H])[C@@](O)1O[C@@]42[C@@]([C@@](C[C@H](O)[C@@]6(O)[C@]([H])5CN7[C@](CC[C@H](C)C7)([H])[C@@](O)6C)(O)[C@@]5(O)C4)([H])CC3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Veratridine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.69 | 50 |
制备储备液 for Veratridine
以下数据基于产品分子量 673.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.97 mL | 14.84 mL | 29.68 mL |
| 2.5 mM | 0.59 mL | 2.97 mL | 5.94 mL |
| 5 mM | 0.3 mL | 1.48 mL | 2.97 mL |
| 25 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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产品说明书 for Veratridine
参考文献 for Veratridine
参考文献是支持产品生物活性的出版物。
McKinney et al (1986) Purification, solubility and pKa of veratridine. Anal.Biochem. 153 33 PMID: 3963380
Maroto et al (1994) Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine. Eur.J.Pharmacol. 270 331 PMID: 7805782
Fekete et al (2009) Mechanism of the persistant sodium current activator veratridine-evoked Ca2+ elevation: implication for epilepsy. J.Neurochem. 111 745 PMID: 19719824
If you know of a relevant reference for Veratridine, please let us know.
关键词: Veratridine, Veratridine supplier, Sodium, channel, opener, neutoxin, Na+, Na, voltage-gated, ion, channels, neurotoxins, Voltage-gated, Channels, 2918, Tocris Bioscience
6 篇 Veratridine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Veratridine 的部分引用包括：
McKeithan et al (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8 766 PMID: 29075196
Agarwal et al (2017) Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron 93 587 PMID: 28132831
Malmersjö et al (2013) Neural progenitors organize in small-world networks to promote cell proliferation. Nat Commun 110 E1524 PMID: 23576737
Bedut et al (2016) High-throughput drug profiling with voltage- and calcium-sensitive fluorescent probes in human iPSC-derived cardiomyocytes. Am J Physiol Heart Circ Physiol 311 H44 PMID: 27199128
Battefeld et al (2016) Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity. Biol Psychiatry 7 11298 PMID: 27161034
Jones et al (2014) Human macrophage SCN5A activates an innate immune signaling pathway for antiviral host defense. J Biol Chem 289 35326 PMID: 25368329
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Veratridine 的评论
平均评分: 5 (基于 2 条评论。)
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Voltage sensitive sodium channel opening.
By
Anonymous on 11/19/2018
分析类型： Ex Vivo
种属： Mouse
Can be used to activate and open voltage sensitive sodium channels in neurons. Elicits rapid reaction when applied directly to tissue.
Increases intracellular Na+ and tissue swelling.
By
Anonymous on 05/02/2018
分析类型： Ex Vivo
种属： Rat
Verstridine is a voltage-gated sodium channel agonist. It increases intracellular Na+ concentration and also induces cellular and tissue swelling. We used at 50 microM to rat brain slices.