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Submit ReviewVH 101, acid
说明： VHL ligand, carboxylic acid functionalized at the benzylic position
化学名： (S)-3-[[[(2S,4R)-1-[(S)-2-(1-Fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidin-2-yl]carbonyl]amino]-3-[4-(4-methylthiazol-5-yl)phenyl]propanoic acid
纯度： ≥98% (HPLC)
生物活性 for VH 101, acid
VH 101, acid is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand with carboxylic acid handle at the benzylic position ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for VH 101, acid
This product is provided for use in onward chemistry. Suitable solvents can be used.
技术数据 for VH 101, acid
| 分子量 | 574.67 |
| 公式 | C28H35FN4O6S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2408341-97-7 |
| PubChem ID | 156701284 |
| InChI Key | IWPNYGPPFCLKCL-QTDGGUCWSA-N |
| Smiles | CC1=C(SC=N1)C2=CC=C([C@H](CC(O)=O)NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(C4(CC4)F)=O)C(C)(C)C)=O)=O)C=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VH 101, acid
参考文献 for VH 101, acid
参考文献是支持产品生物活性的出版物。
Kofink et al (2022) A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. ChemRxiv - not yet peer reviewed 13 5969 PMID: 36216795
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia