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VH 101, thiol

Cat. No. 7884 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Thiol functionalized VHL ligand
化学名： (2S,4R)-1-[(2R)-2-[[(1-Fluorocyclopropyl)carbonyl]amino]-3-methyl-3-sulfanyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
纯度： ≥95% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for VH 101, thiol

VH 101, thiol is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC® research and development; incorporates an E3 ligase ligand with terminal thiol ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for VH 101, thiol

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for VH 101, thiol

分子量 534.67
公式 C25H31FN4O4S2
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2358775-81-0
InChI Key RCVHBJGYHDKFGZ-WSTZPKSXSA-N
Smiles O=C(C1(CC1)F)N[C@@H](C(C)(S)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(N=CS4)C)C=C3)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for VH 101, thiol

参考文献是支持产品生物活性的出版物。

Liu et al (2022) Discovery of XL01126: a potent, fast, cooperative, selective, orally bioavailable, and blood-brain barrier penetrant PROTAC degrader of leucine-rich repeat kinase 2. J.Am.Chem.Soc. 144 16930 PMID: 36007011

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia