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Submit ReviewVigabatrin
说明： GABA-T inhibitor
别名： (±)-γ-Vinyl GABA
化学名： 4-Aminohexenoic acid
纯度： ≥98% (HPLC)
生物活性 for Vigabatrin
Vigabatrin is a selective GABA-T (transaminase) inhibitor. Anticonvulsant.
技术数据 for Vigabatrin
| 分子量 | 129.16 |
| 公式 | C6H11NO2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 68506-86-5 |
| PubChem ID | 5665 |
| InChI Key | PJDFLNIOAUIZSL-UHFFFAOYSA-N |
| Smiles | NC(C=C)CCC(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Vigabatrin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 12.92 | 100 |
制备储备液 for Vigabatrin
以下数据基于产品分子量 129.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 7.74 mL | 38.71 mL | 77.42 mL |
| 5 mM | 1.55 mL | 7.74 mL | 15.48 mL |
| 10 mM | 0.77 mL | 3.87 mL | 7.74 mL |
| 50 mM | 0.15 mL | 0.77 mL | 1.55 mL |
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产品说明书 for Vigabatrin
参考文献 for Vigabatrin
参考文献是支持产品生物活性的出版物。
Halonen et al (1991) Effects of vigab. (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats. Epilepsia 32 242 PMID: 1672276
Larsson et al (1986) Differential effect of gamma-vinyl GABA and valproate on GABA transaminase from cultured neurones and astrocytes. Neuropharmacology 25 617 PMID: 3092125
Schmid et al (1996) Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon. J.Pharmacol.Exp.Ther. 276 977 PMID: 8786578
If you know of a relevant reference for Vigabatrin, please let us know.
关键词: Vigabatrin, Vigabatrin supplier, GABA-T, inhibitors, inhibits, GABA-Transferase, Transferases, GABA, GABAA, GABAC, Receptors, GABAB, (±)-γ-Vinyl, (±)-gamma-Vinyl, 60643-86-9, (±)-g-Vinyl, Miscellaneous, Other, 0808, Tocris Bioscience
2 篇 Vigabatrin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Vigabatrin 的部分引用包括：
Héja et al (2009) Glutamate uptake triggers transporter-mediated GABA release from astrocytes. Stem Cells Dev 4 e7153 PMID: 19777062
Walters et al (2019) Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use-limiting visual field defects. Pharmacol Res Perspect 7 e00456 PMID: 30631446
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.