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Submit ReviewVismodegib
说明： Potent hedgehog pathway inhibitor
化学名： 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide
纯度： ≥98% (HPLC)
生物活性 for Vismodegib
Vismodegib is a potent hedgehog pathway inhibitor (IC50 = 3 nM). It causes tumor regressions in allograft medulloblastoma mice model and tumor growth inhibition in a xenograft mouse models of colorectal cancer. Vismodegib is orally bioavailable.
技术数据 for Vismodegib
| 分子量 | 421.3 |
| 公式 | C19H14Cl2N2O3S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 879085-55-9 |
| PubChem ID | 24776445 |
| InChI Key | BPQMGSKTAYIVFO-UHFFFAOYSA-N |
| Smiles | O=C(NC=1C=CC(Cl)=C(C1)C2=NC=CC=C2)C3=CC=C(C=C3Cl)S(=O)(=O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Vismodegib
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 42.13 | 100 |
制备储备液 for Vismodegib
以下数据基于产品分子量 421.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.87 mL | 23.74 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.75 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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产品说明书 for Vismodegib
参考文献 for Vismodegib
参考文献是支持产品生物活性的出版物。
Robarge et al (2009) GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorg.Med.Chem.Lett. 19 5576 PMID: 19716296
Wong et al (2009) Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor. Xenobiotica 39 850 PMID: 19845436
Wong et al (2011) Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. Clin.Cancer Res. 17 4682 PMID: 21610148
If you know of a relevant reference for Vismodegib, please let us know.
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关键词: Vismodegib, Vismodegib supplier, potent, inhibitors, hedgehog, Hh, pathway, signaling, inhibits, Signalling, orally, bioavailable, Hedgehog, Signaling, 7710, Tocris Bioscience
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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