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VO-OHpic

Cat. No. 3591 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent PTEN inhibitor
化学名： (OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxovanadate(1-),hydrogen
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for VO-OHpic

VO-OHpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.

技术数据 for VO-OHpic

分子量 361.16
公式 C12H10N2O8V
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 675848-25-6
PubChem ID 90488861
InChI Key WUAQQAGTKWKWKQ-UHFFFAOYSA-K
Smiles OC1=C2C([O-][V+2]3(O)([O-]C(C4=NC=CC=C4[O-]3)=O)([N]2=CC=C1)=O)=O.[H+]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VO-OHpic

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.12 100

制备储备液 for VO-OHpic

以下数据基于产品分子量 361.16。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.69 mL
5 mM 0.55 mL 2.77 mL 5.54 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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参考文献 for VO-OHpic

参考文献是支持产品生物活性的出版物。

Rosivatz et al (2006) A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem.Biol. 1 780 PMID: 17240976

Sharma et al (2015) The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci.Adv. 1 e1500845 PMID: 26601142

If you know of a relevant reference for VO-OHpic, please let us know.

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关键词: VO-OHpic, VO-OHpic supplier, 476310-60-08, potent, inhibitors, inhibits, PTEN, phosphate, tensin, homolog, deleted, chromosome, 10, Protein, Tyrosine, Phosphatases, 3591, Tocris Bioscience

1 篇 VO-OHpic 的引用文献

引用文献是使用了 Tocris 产品的出版物。 VO-OHpic 的部分引用包括：

Justyna et al (2022) Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic Neurons. Biomolecules 12 PMID: 35454152

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