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Submit ReviewVU 0155041 sodium salt
Discontinued Product
3311 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
说明： Potent positive allosteric modulator of mGlu4 receptors; sodium salt of VU 0155041 (Cat. No. 3248)
化学名： cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid sodium salt
纯度： ≥98% (HPLC)
生物活性 for VU 0155041 sodium salt
VU 0155041 sodium salt is a potent, positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors respectively). Active in in vivo models of Parkinson's disease following i.c.v. administration. Sodium salt of VU 0155041 (Cat. No. 3248).
技术数据 for VU 0155041 sodium salt
| 分子量 | 338.16 |
| 公式 | C14H14Cl2NNaO3 |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1259372-69-4 |
| PubChem ID | 90488828 |
| InChI Key | ISTRFEKLZQLUBR-ZQMRVLLOSA-L |
| Smiles | [Na+].[Na+].[O-]C(=O)[C@H]1CCCC[C@H]1C(=O)NC1=CC(Cl)=CC(Cl)=C1.[O-]C(=O)[C@@H]1CCCC[C@@H]1C(=O)NC1=CC(Cl)=CC(Cl)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VU 0155041 sodium salt
参考文献 for VU 0155041 sodium salt
参考文献是支持产品生物活性的出版物。
Niswender et al (2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol.Pharmacol. 74 1345 PMID: 18664603
关键词: VU 0155041 sodium salt, VU 0155041 sodium salt supplier, Potent, positive, allosteric, mGlu4, mGluR4, agonists, Sodium, salt, mGlur, Group, III, Receptors, Glutamate, Metabotropic, VU0155041, sodium, PAM, (Metabotropic), 3311, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.