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Submit ReviewVU 0285683
Discontinued Product
4381 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
说明： Negative allosteric modulator of mGlu5 receptors
化学名： 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile
纯度： ≥98% (HPLC)
生物活性 for VU 0285683
VU 0285683 is a negative allosteric modulator of mGlu5 receptors. Displays high affinity for the MPEP (Cat. No. 1212) binding site; acts as a full antagonist and blocks the glutamate response to mGlu5 (IC50 = 24.4 nM). Selective for mGlu5 over mGlu1, mGlu3 and mGlu4. Exhibits anxiolytic activity in rodent models of anxiety. Analog available (Cat. No. 4323).
技术数据 for VU 0285683
| 分子量 | 266.23 |
| 公式 | C14H7FN4O |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 327056-22-4 |
| PubChem ID | 9816778 |
| InChI Key | GELAFISMURFRCA-UHFFFAOYSA-N |
| Smiles | FC1=CC(C#N)=CC(C2=NC(C3=NC=CC=C3)=NO2)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VU 0285683
参考文献 for VU 0285683
参考文献是支持产品生物活性的出版物。
Rodriguez (2010) Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol.Pharmacol. 78 1105 PMID: 20923853
关键词: VU 0285683, VU 0285683 supplier, Negative, allosteric, modulators, mGlu5, mGluR5, mGlur, Group, I, Receptors, Glutamate, Metabotropic, MPEP, binding, site, VU0285683, nams, (Metabotropic), 4381, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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