VU 0357017 hydrochloride

Cat. No. 4295 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Positive allosteric modulator of M₁ receptors

化学名： 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester hydrochloride

纯度： ≥98% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for VU 0357017 hydrochloride

VU 0357017 hydrochloride is a positive allosteric modulator of muscarinic M₁ receptors (EC₅₀ = 198 nM). Displays no activity at M₂-M₅ at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.

技术数据 for VU 0357017 hydrochloride

分子量	369.89
公式	C₁₈H₂₇N₃O₃.HCl
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	1135242-13-5
PubChem ID	25010775
InChI Key	XKJQVUIXSBOCPP-UHFFFAOYSA-N
Smiles	CC1=CC=CC=C1C(NCCNC2CCN(C(OCC)=O)CC2)=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VU 0357017 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	9.25	25
	DMSO	1.85	5

制备储备液 for VU 0357017 hydrochloride

以下数据基于产品分子量 369.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	10.81 mL	54.07 mL	108.14 mL
1.25 mM	2.16 mL	10.81 mL	21.63 mL
2.5 mM	1.08 mL	5.41 mL	10.81 mL
12.5 mM	0.22 mL	1.08 mL	2.16 mL

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产品说明书 for VU 0357017 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for VU 0357017 hydrochloride

参考文献是支持产品生物活性的出版物。

Bridges et al (2010) Chemical lead optimization of a pan G_q mAChR M₁, M₃, M₅ positive allosteric modulator (PAM) Lead. Part II. Development of potent and highly selective M₁ PAM. Bioorg.Med.Chem.Lett. 20 1972 PMID: 20156687

Lebois et al (2010) Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M₁ receptor function in the central nervous system. ACS Chem.Neurosci. 1 104

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关键词: VU 0357017 hydrochloride, VU 0357017 hydrochloride supplier, VU0357017, hydrochloride, muscarinics, acetylcholine, machrs, positive, allosteric, modulators, pams, m1, selective, M1, Receptors, 4295, Tocris Bioscience

3 篇 VU 0357017 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 VU 0357017 hydrochloride 的部分引用包括：

Pasko et al (2020) Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex. Neuron 106 649-661.e4 PMID: 32197063

Stefan et al (2018) Muscarinic M1 Receptor Overstimulation Disrupts Working Memory Activity for Rules in Primate Prefrontal Cortex. Neuron 98 1256-1268.e4 PMID: 29887340

Jadeja et al (2016) Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress. J Am Soc Nephrol 6 405 PMID: 26862589

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