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Submit ReviewVU 0357121
Discontinued Product
4437 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
说明： Positive allosteric modulator of mGlu5 receptors
化学名： 4-Butoxy-N-(2,4-difluorophenyl)benzamide
纯度： ≥99% (HPLC)
生物活性 for VU 0357121
VU 0357121 is a positive allosteric modulator of mGlu5 receptors (EC50 = 33 nM). Binds to a site distinct from that bound by MPEP (Cat. No. 1212).
技术数据 for VU 0357121
| 分子量 | 305.32 |
| 公式 | C17H17F2NO2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 433967-28-3 |
| PubChem ID | 2296132 |
| InChI Key | AHCYOTLTLQTPSU-UHFFFAOYSA-N |
| Smiles | O=C(NC2=C(F)C=C(F)C=C2)C1=CC=C(OCCCC)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VU 0357121
参考文献 for VU 0357121
参考文献是支持产品生物活性的出版物。
Hammond et al (2010) Discovery of a novel chemical class of mGlu5 allosteric ligands with distinct modes of pharmacology. ACS Chem.Neurosci. 1 702 PMID: 20981342
关键词: VU 0357121, VU 0357121 supplier, VU0357121, pams, positive, allosteric, modulators, mglu5, receptors, mglur5, Glutamate, (Metabotropic), Group, I, Receptors, 4437, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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