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Submit ReviewVU 0360223
Discontinued Product
4394 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
说明： Negative allosteric modulator of mGlu5 receptors
化学名： 3-Fluoro-5-(2-methyl-5-benzothiazolyl)-benzonitrile
纯度： ≥99% (HPLC)
生物活性 for VU 0360223
VU 0360223 is a potent negative allosteric modulator of mGlu5 (IC50 = 61 nM). Displays no activity at mGlu1-4 and mGlu7-8.
技术数据 for VU 0360223
| 分子量 | 268.31 |
| 公式 | C15H9FN2S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1274859-33-4 |
| PubChem ID | 45103530 |
| InChI Key | WDHYUBIJZHYUOV-UHFFFAOYSA-N |
| Smiles | CC2=NC1=CC(C3=CC(F)=CC(C#N)=C3)=CC=C1S2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VU 0360223
参考文献 for VU 0360223
参考文献是支持产品生物活性的出版物。
Lindsley et al (2011) (3-cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu5: discovery of a new tool compound with activity in the OSS mouse model of addiction. ACS Chem.Neurosci. 2 471 PMID: 21927650
关键词: VU 0360223, VU 0360223 supplier, VU0360223, potent, negative, allosteric, modulators, nams, mglu5, Glutamate, (Metabotropic), Group, I, Receptors, 4394, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.