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Submit ReviewVU 0364439
Discontinued Product
4371 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
说明： Positive allosteric modulator of mGlu4 receptors
化学名： N-[3-Chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-2-pyridinecarboxamide
纯度： ≥99% (HPLC)
生物活性 for VU 0364439
VU 0364439 is a positive allosteric modulator (PAM) of mGlu4 receptors (EC50 = 19.8 nM in vitro for human mGlu4).
技术数据 for VU 0364439
| 分子量 | 422.29 |
| 公式 | C18H13Cl2N3O3S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1246086-78-1 |
| PubChem ID | 46934289 |
| InChI Key | IXHCGJXBIHHIEF-UHFFFAOYSA-N |
| Smiles | O=C(NC2=CC(Cl)=C(S(NC3=C(Cl)C=CC=C3)(=O)=O)C=C2)C1=NC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VU 0364439
参考文献 for VU 0364439
参考文献是支持产品生物活性的出版物。
Engers et al (2010) Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators (PAMs) identified by functional high-throughput screening (HTS). Bioorg.Med.Chem.Lett. 20 5175 PMID: 20667732
Robichaud et al (2011) Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics. ACS Chem.Neurosci. 2 433
关键词: VU 0364439, VU 0364439 supplier, VU0364439, potent, mGlu4, mGluR4, postive, allosteric, modulators, PAMs, metabotropic, glutamate, 4, receptors, Glutamate, (Metabotropic), Group, III, Receptors, 4371, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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