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Submit ReviewVU 0364770
Discontinued Product
4469 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
说明： Positive allosteric modulator of mGlu4 receptors
化学名： N-(3-Chlorophenyl)-2-pyridinecarboxamide
纯度： ≥99% (HPLC)
生物活性 for VU 0364770
VU 0364770 is a positive allosteric modulator at mGlu4 receptors (EC50 = 290 nM in mGlu4-expressing HEK 293 cells). Reverses haloperidol-induced catalepsy in rats; prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Exhibits affinity for MAO-B and MAO-A (Ki values are 0.72 μM and 8.5 μM respectively). Brain penetrant.
技术数据 for VU 0364770
| 分子量 | 232.67 |
| 公式 | C12H9ClN2O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 61350-00-3 |
| PubChem ID | 836002 |
| InChI Key | SUYUTNCKIOLMAJ-UHFFFAOYSA-N |
| Smiles | O=C(C2=NC=CC=C2)NC1=CC=CC(Cl)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VU 0364770
参考文献 for VU 0364770
参考文献是支持产品生物活性的出版物。
Jones et al (2012) The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J.Pharmacol.Exp.Ther. 340 404 PMID: 22088953
关键词: VU 0364770, VU 0364770 supplier, VU0364770, glutamate, receptor, Glu, mGlu4, mGluR4, postive, allosteric, modulators, pams, brain, penetrant, Glutamate, (Metabotropic), Group, III, Receptors, 4469, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.