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说明： Positive allosteric modulator of M5 receptors
化学名： 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
纯度： ≥98% (HPLC)
生物活性 for VU 0365114
VU 0365114 is a selective positive allosteric modulator of M5 (EC50 values are 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4 receptors).
技术数据 for VU 0365114
| 分子量 | 397.35 |
| 公式 | C22H14F3NO3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1208222-39-2 |
| PubChem ID | 45281794 |
| InChI Key | SPBGRXOPAXZSER-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC(OC(F)(F)F)=CC=C1N2CC3=CC=C(C4=CC=CC=C4)C=C3)C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VU 0365114
参考文献 for VU 0365114
参考文献是支持产品生物活性的出版物。
Bridges et al (2010) Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: development of the first highly selective M5 PAM. Bioorg.Med.Chem.Lett. 20 558 PMID: 20004578
Bridges et al (2010) Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg.Med.Chem.Lett. 20 5617 PMID: 20801651
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关键词: VU 0365114, VU 0365114 supplier, VU0365114, acetylcholine, muscarinics, machrs, receptors, positive, allosteric, modulators, pams, m5, M5, Receptors, 4404, Tocris Bioscience
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