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Submit ReviewVU 0422288
说明： Selective positive allosteric modulator of group III mGlu receptors
别名： ML 396
化学名： N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for VU 0422288
VU 0422288 is a group III mGlu receptor positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively). Exhibits selectivity over a panel of 68 other GPCRs, ion channels and transporters. Potentiates mGlu7-mediated reductions in excitatory post synaptic potentials in hippocampal slices.
技术数据 for VU 0422288
| 分子量 | 360.19 |
| 公式 | C17H11Cl2N3O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1630936-95-6 |
| PubChem ID | 73058507 |
| InChI Key | MZRLPXFGQKQHST-UHFFFAOYSA-N |
| Smiles | ClC1=CC(NC(C3=CC=CC=N3)=O)=CC=C1OC2=CC=C(Cl)C=N2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for VU 0422288
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 36.02 | 100 |
制备储备液 for VU 0422288
以下数据基于产品分子量 360.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.78 mL | 13.88 mL | 27.76 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.55 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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产品说明书 for VU 0422288
参考文献 for VU 0422288
参考文献是支持产品生物活性的出版物。
Jalan-Sakrikar et al (2014) Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem.Neurosci. 5 1221 PMID: 25225882
If you know of a relevant reference for VU 0422288, please let us know.
关键词: VU 0422288, VU 0422288 supplier, VU0422288, ML396, groupIII, mglu4, mglu8, mglu7, metabotropic, receptors, positive, allosteric, modulators, selective, PAM, ML, 396, Glutamate, (Metabotropic), Group, III, Receptors, 5378, Tocris Bioscience
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