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Submit ReviewVU 0469650 hydrochloride
说明： Potent and selective negative allosteric modulator of mGlu1 receptors
化学名： 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride
纯度： ≥98% (HPLC)
生物活性 for VU 0469650 hydrochloride
VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). Exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. Brain penetrant.
技术数据 for VU 0469650 hydrochloride
| 分子量 | 400.94 |
| 公式 | C22H28N4O.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1443748-47-7 |
| PubChem ID | 71680759 |
| InChI Key | YENVAZRENOYZGQ-GUIQYPADSA-N |
| Smiles | O=C(N4CCN(C5=C(C#N)N=CC=C5)C[C@H]4C)C12CC(C3)CC(CC3C2)C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for VU 0469650 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 40.09 | 100 | |
| ethanol | 20.05 | 50 |
制备储备液 for VU 0469650 hydrochloride
以下数据基于产品分子量 400.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.49 mL | 12.47 mL | 24.94 mL |
| 5 mM | 0.5 mL | 2.49 mL | 4.99 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.49 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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产品说明书 for VU 0469650 hydrochloride
参考文献 for VU 0469650 hydrochloride
参考文献是支持产品生物活性的出版物。
Lovell et al (2013) N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg.Med.Chem.Lett. 23 3713 PMID: 23727046
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关键词: VU 0469650 hydrochloride, VU 0469650 hydrochloride supplier, VU0469650, hydrochloride, modulators, metabotropic, glutamate, receptor, mGlu1, mGluR1, allosteric, negative, potent, selective, NAMs, Glutamate, (Metabotropic), Group, I, Receptors, 5379, Tocris Bioscience
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