VU 0483605

Discontinued Product

5377 has been discontinued.

View all Glutamate (Metabotropic) Group I Receptors products.
说明: Positive allosteric modulator of mGlu1 receptors
化学名: 3-Chloro-N-[3-chloro-4-(4-chloro-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-pyridinecarboxamide
纯度: ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (5)

生物活性 for VU 0483605

Positive allosteric modulator at mGlu1 (EC50 values are 356 and 390 nM for rat and human receptors, respectively). Exhibits >25-fold selectivity for mGlu1 over mGlu4. Potentiates the decreased glutamate-induced calcium response in mGlu1 mutant cell models of schizophrenia.

技术数据 for VU 0483605

分子量 446.67
公式 C20H10Cl3N3O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1623101-11-0
PubChem ID 91885483
InChI Key HJQXPBKPTGWZCF-UHFFFAOYSA-N
Smiles ClC1=C2C(C(N(C3=CC=C(NC(C4=C(Cl)C=CC=N4)=O)C=C3Cl)C2=O)=O)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for VU 0483605

参考文献是支持产品生物活性的出版物。

Cho et al (2014) Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. ACS Chem.Biol. 9 2334 PMID: 25137254

关键词: VU 0483605, VU 0483605 supplier, VU0483605, positive, allosteric, modulators, PAMs, mglu1, metabotropic, glutamate, receptors, schizophrenia, Glutamate, (Metabotropic), Group, I, Receptors, 5377, Tocris Bioscience

1 篇 VU 0483605 的引用文献

引用文献是使用了 Tocris 产品的出版物。 VU 0483605 的部分引用包括:

Hellyer et al (2018) "Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands. Mol.Pharmacol. 93 504 PMID: 29514854


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