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VU 10010

Cat. No. 3141 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective positive allosteric modulator of M4 receptors
化学名： 3-Amino-N-[(4-chlorophenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for VU 10010

VU 10010 is a selective allosteric potentiator of M4 acetylcholine receptors (EC50 values are 33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively). Binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.

技术数据 for VU 10010

分子量 345.85
公式 C17H16ClN3OS
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 633283-39-3
PubChem ID 714286
InChI Key FPRULFHDSFKYBV-UHFFFAOYSA-N
Smiles CC1=C2C(SC(C(NCC3=CC=C(Cl)C=C3)=O)=C2N)=NC(C)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VU 10010

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.59 100
ethanol 3.46 10

制备储备液 for VU 10010

以下数据基于产品分子量 345.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.89 mL 14.46 mL 28.91 mL
5 mM 0.58 mL 2.89 mL 5.78 mL
10 mM 0.29 mL 1.45 mL 2.89 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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参考文献 for VU 10010

参考文献是支持产品生物活性的出版物。

Shirey et al (2008) An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat.Chem.Biol. 4 42 PMID: 18059262

If you know of a relevant reference for VU 10010, please let us know.

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关键词: VU 10010, VU 10010 supplier, Selective, allosteric, potentiator, M4, receptors, Muscarinic, Receptors, Acetylcholine, ACh, VU10010, PAM, 3141, Tocris Bioscience

1 篇 VU 10010 的引用文献

引用文献是使用了 Tocris 产品的出版物。 VU 10010 的部分引用包括：

Bell et al (2015) Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation. PLoS One 9 115 PMID: 25918499

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