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Submit ReviewVUF 10460
Discontinued Product
4769 has been discontinued.
View all Histamine H<sub>4</sub> Receptors products.
说明： Selective H4 agonist
化学名： 4-(4-Methyl-1-piperazinyl)-6-phenyl-2-Pyrimidinamine
纯度： ≥98% (HPLC)
生物活性 for VUF 10460
VUF 10460 is a selective histamine H4 receptor agonist; displays 50-fold selectivity for the rat H4 receptor over the H3 subtype (pKi values are 5.75 and 7.46 for rat H3 and H4 receptors respectively). Also exhibits affinity for the human H4 receptor (pKi = 8.22).
技术数据 for VUF 10460
| 分子量 | 269.34 |
| 公式 | C15H19N5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1028327-66-3 |
| PubChem ID | 25129523 |
| InChI Key | NIJGWJIOMPHDBP-UHFFFAOYSA-N |
| Smiles | NC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VUF 10460
参考文献 for VUF 10460
参考文献是支持产品生物活性的出版物。
Altenbach et al (2008) Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands. J.Med.Chem. 51 6571 PMID: 18811133
Cowart et al (2008) Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J.Med.Chem. 51 6547 PMID: 18817367
Coruzzi et al (2011) Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach. Eur.J.Pharmacol. 669 121 PMID: 21839070
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关键词: VUF 10460, VUF 10460 supplier, VUF10460, histamine, histaminergic, H4, receptors, agonists, selective, Histamine, Receptors, 4769, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.