VUF 8430 dihydrobromide

Name: VUF 8430 dihydrobromide
Brand: Tocris Bioscience
SKU: 2494

Cat. No. 2494 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2494 has been discontinued.

View all Histamine H<sub>4</sub> Receptors products.

说明： Potent and high affinity H₄ agonist

化学名： 2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester dihydrobromide

说明书

引用文献 (1)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for VUF 8430 dihydrobromide

VUF 8430 dihydrobromide is a high affinity (pK_i = 7.5), potent histamine H₄ receptor full agonist (pEC₅₀ = 7.3). Displays moderate affinity for H₃ receptors (pK_i = 6.0) and weak partial agonist activity at H₂ receptors.

技术数据 for VUF 8430 dihydrobromide

分子量	323.05
公式	C₄H₁₁N₅S.2HBr
储存	Desiccate at RT
CAS Number	100130-32-3
PubChem ID	3063227
InChI Key	GPWJSTKHQMIXCA-UHFFFAOYSA-N
Smiles	Br.Br.NC(SCCNC(N)=N)=N

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for VUF 8430 dihydrobromide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for VUF 8430 dihydrobromide

参考文献是支持产品生物活性的出版物。

Sterk et al (1986) The influence of guanidio and isothiourea groups in histaminergic compounds on H₂-activity. Agents Actions 18 137 PMID: 2942013

Lim et al (2006) Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H₄ receptor agonist. J.Med.Chem. 49 6650 PMID: 17154494

Lim et al (2008) Phenylalanine 169 in the second extracellular loop of the human histamine H₄ receptor is responsible for the difference in agonist binding between human and mouse H₄ receptors. J.Pharmacol.Exp.Ther. 327 88 PMID: 18635748

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关键词: VUF 8430 dihydrobromide, VUF 8430 dihydrobromide supplier, Potent, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, VUF8430, dihydrobromide, 2494, Tocris Bioscience

1 篇 VUF 8430 dihydrobromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 VUF 8430 dihydrobromide 的部分引用包括：

Lamas et al (2014) Enhancement of ionizing radiation response by histamine in vitro and in vivo in human breast cancer. Cancer Biol Ther 16 137 PMID: 25482934