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Submit ReviewVX 702
说明： Orally active p38α and p38β inhibitor
化学名： 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for VX 702
Orally active, ATP-competitive inhibitor of p38α MAPK; also inhibits p38β (KD values are 3.7 and 17 nM respectively).
技术数据 for VX 702
| 分子量 | 404.32 |
| 公式 | C19H12F4N4O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 745833-23-2 |
| PubChem ID | 10341154 |
| InChI Key | FYSRKRZDBHOFAY-UHFFFAOYSA-N |
| Smiles | NC(N(C3=C(F)C=CC=C3F)C1=CC=C(C(N)=O)C(C2=C(F)C=C(F)C=C2)=N1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VX 702
参考文献 for VX 702
参考文献是支持产品生物活性的出版物。
Din (2006) Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome. Curr.Opin.Investig.Drugs 7 1020 PMID: 17117592
Goldstein et al (2010) Selective p38α inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J.Med.Chem. 53 2345 PMID: 19950901
Damjanov et al (2009) Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis. Arthrit.Rheumat. 60 1232
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关键词: VX 702, VX 702 supplier, VX702, orally, active, p38α, p38alpha, p38a, p38β, p38beta, p38b, inhibitors, inhibits, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, 479543-46-9, p38, 3916, Tocris Bioscience
2 篇 VX 702 的引用文献
引用文献是使用了 Tocris 产品的出版物。 VX 702 的部分引用包括：
Baudet et al (2012) RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion. Blood 119 6255 PMID: 22555972
O'Sullivan et al (2016) Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions inhuman astrocytes. Journal of Neuroinflammation 13 189 PMID: 27549131
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for VX 702
