Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewVX 702
说明： Orally active p38α and p38β inhibitor
化学名： 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
纯度： ≥98% (HPLC)
生物活性 for VX 702
Orally active, ATP-competitive inhibitor of p38α MAPK; also inhibits p38β (KD values are 3.7 and 17 nM respectively).
技术数据 for VX 702
| 分子量 | 404.32 |
| 公式 | C19H12F4N4O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 745833-23-2 |
| PubChem ID | 10341154 |
| InChI Key | FYSRKRZDBHOFAY-UHFFFAOYSA-N |
| Smiles | NC(N(C3=C(F)C=CC=C3F)C1=CC=C(C(N)=O)C(C2=C(F)C=C(F)C=C2)=N1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for VX 702
参考文献 for VX 702
参考文献是支持产品生物活性的出版物。
Din (2006) Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome. Curr.Opin.Investig.Drugs 7 1020 PMID: 17117592
Goldstein et al (2010) Selective p38α inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J.Med.Chem. 53 2345 PMID: 19950901
Damjanov et al (2009) Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis. Arthrit.Rheumat. 60 1232
按标靶查看相关产品
按产品操作查看相关产品
关键词: VX 702, VX 702 supplier, VX702, orally, active, p38α, p38alpha, p38a, p38β, p38beta, p38b, inhibitors, inhibits, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, 479543-46-9, p38, 3916, Tocris Bioscience
2 篇 VX 702 的引用文献
引用文献是使用了 Tocris 产品的出版物。 VX 702 的部分引用包括：
O'Sullivan et al (2016) Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions inhuman astrocytes. Journal of Neuroinflammation 13 189 PMID: 27549131
Baudet et al (2012) RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion. Blood 119 6255 PMID: 22555972
VX 702 的评论
目前没有该产品的评论。 Be the first to review VX 702 and earn rewards!
Have you used VX 702?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for VX 702
