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Submit Reviewω-Conotoxin GVIA
说明： CaV2.2 blocker
纯度： ≥95% (HPLC)
生物活性 for ω-Conotoxin GVIA
ω-Conotoxin GVIA is a peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG (Cat. No. 0342)-induced long term depression in vivo.
技术数据 for ω-Conotoxin GVIA
| 分子量 | 3037 |
| 公式 | C120H182N38O43S6 |
| 序列 |
CKSXGSSCSXTSYNCCRSCNXYTKRCY (Modifications: X = Hyp, Disulfide bridges: 1-16, 8-19, 15-26, Tyr-27 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 106375-28-4 |
| PubChem ID | 90479753 |
| InChI Key | DRVGOMCWRXUORL-QPEMYEDGSA-N |
| Smiles | [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)C4C(O)CCN4C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)C4C(O)CCN4C(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CO)C(=O)N1CCC(O)C1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N3)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ω-Conotoxin GVIA
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for ω-Conotoxin GVIA
参考文献 for ω-Conotoxin GVIA
参考文献是支持产品生物活性的出版物。
Tsien et al (1988) Multiple types of neuronal calcium channels and their selective modulation. TiNS 11 431 PMID: 2469160
Wright and Angu (1997) Prolonged cardiovascular effects of the N-type Ca2+ channel antagonist ω-conotoxin GVIA in conscious rabbits. J.Cardiovasc.Pharmacol. 30 392 PMID: 9300325
Connelly et al (2011) Distinct mechanisms contribute to agonist and synaptically induced metabotropic glutamate receptor long-term depression. Eur.J.Pharmacol. 667 160 PMID: 21575629
Sato et al (1993) Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels. Biochem.Biophys.Res.Comm. 194 1292 PMID: 8394704
If you know of a relevant reference for ω-Conotoxin GVIA, please let us know.
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关键词: w-Conotoxin GVIA, w-Conotoxin GVIA supplier, Ca2+, channel, blockers, N-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, omega-Conotoxin, ω-conotoxin, GVIA, neurotoxins, venoms, Cav2.x, 1085, Tocris Bioscience
15 篇 ω-Conotoxin GVIA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ω-Conotoxin GVIA 的部分引用包括：
Grubb and Burrone (2010) Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability. J Pharmacol Exp Ther 465 1070 PMID: 20543823
Chang (2010) Dynamic modulation of phasic and asynchronous glutamate release in hippocampal synapses. J Neurophysiol 103 392 PMID: 19889850
Perissinotti et al (2015) Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice. Proc Natl Acad Sci U S A 8 444 PMID: 25610372
Smith et al (2013) Comparative functional expression of nAChR subtypes in rodent DRG neurons. Front Cell Neurosci 7 225 PMID: 24348328
Kim and Alger (2010) Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. Nat Neurosci 13 592 PMID: 20348918
Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Front Cell Neurosci 11 e0154932 PMID: 27183222
Schuwald et al (2013) Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels. J Neurosci 8 e59998 PMID: 23637742
Medrihan et al (2013) Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels. Nature 4 1512 PMID: 23443540
Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. Addict Biol 350 290 PMID: 24891452
Mahler et al (2014) Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. J Neurosci 19 49 PMID: 23017017
Szabó et al (2014) Presynaptic calcium channel inhibition underlies CB1 cannabinoid receptor-mediated suppression of GABA release. PLoS One 34 7958 PMID: 24899717
Chu et al (2009) Secr. as a neurohypophysial factor regulating body water homeostasis. PLoS One 106 15961 PMID: 19805236
Bellono (2017) Molecular basis of ancestral vertebrate electroreception. Nature 543 391 PMID: 28264196
Izzo et al (2012) Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. Br J Pharmacol 166 1444 PMID: 22300105
Haeberle et al (2004) Molecular profiling reveals synaptic release machinery in Merkel cells. Proc Natl Acad Sci U S A 101 14503 PMID: 15448211
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ω-Conotoxin GVIA 的评论
平均评分: 4.7 (基于 3 条评论。)
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The pharmacological inhibitors for electrophysiology assay.
By
Anonymous on 02/28/2020
分析类型： In Vitro
种属： Other
The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound.
By
Anonymous on 02/01/2020
分析类型： In Vitro
种属： Other
Biologically active compounds that have been documented to interact with awide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat.# 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience
omega -Conotoxin suppresses field EPSP amplitude.
By
Anonymous on 06/12/2019
分析类型： Ex Vivo
种属： Rat
细胞系/组织： Anterior cingulate cortex
Experiment to test dependence of field EPSPs in neural tissue from N-type Ca2+ channels. 10 min incubation with 25 microM omega -Conotoxin GVIA decreased significantly fEPSP amplitude. Blue: control. Red: after incubation with omega -Conotoxin GVIA.
