Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Reviewω-Conotoxin MVIIC
说明： CaV2.x blocker
生物活性 for ω-Conotoxin MVIIC
ω-Conotoxin MVIIC is a peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.
许可信息
Sold under license from the University of Utah.
技术数据 for ω-Conotoxin MVIIC
| 分子量 | 2749 |
| 公式 | C106H178N40O32S7 |
| 序列 |
CKGKGAPCRKTMYDCCSGSCGRRGKC (Modifications: Disulfide bridges: 1-16, 8-20, 15-26, Cys-26 = C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 147794-23-8 |
| PubChem ID | 90479752 |
| InChI Key | FHVUTHWUIUXZBY-IXEXBNPISA-N |
| Smiles | [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]4CCCN4C(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)NC([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N3)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC2=O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ω-Conotoxin MVIIC
参考文献 for ω-Conotoxin MVIIC
参考文献是支持产品生物活性的出版物。
Hillyard et al (1992) A new conus peptide ligand for mammalian presynaptic Ca2+ channels. Neuron 9 69 PMID: 1352986
McDonough et al (1996) Inhibition of Ca2+ channels in rat central and peripheral neurons by ω-conotoxin MVIIC. J.Neurosci. 16 2612 PMID: 8786437
按产品操作查看相关产品
关键词: w-Conotoxin MVIIC, w-Conotoxin MVIIC supplier, Ca2+, channel, blockers, N-type, P-type, Q-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, omega-Conotoxin, ω-conotoxin, MVIIC, neurotoxins, venoms, Cav2.x, 1084, Tocris Bioscience
11 篇 ω-Conotoxin MVIIC 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ω-Conotoxin MVIIC 的部分引用包括：
Smith et al (2013) Comparative functional expression of nAChR subtypes in rodent DRG neurons. Front Cell Neurosci 7 225 PMID: 24348328
Hanlon et al (2016) Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent. Breast Cancer (Dove Med Press) 8 59 PMID: 27186076
Schöbel et al (2014) Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds. Chem Senses 39 471 PMID: 24718416
Maier et al (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem 285 35606 PMID: 20826795
Pascual-Caro et al (2018) STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry. J Mol Med (Berl) 96 1061 PMID: 30088035
Fortalezas et al (2018) Methyl-β-Cyclodextrin Impairs the Phosphorylation of the β2 Subunit of L-Type Calcium Channels and Cytosolic Calcium Homeostasis in Mature Cerebellar Granule Neurons. Int J Mol Sci 19 PMID: 30463327
Luca et al (2017) Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents. Neuron 95 63 PMID: 28683270
Haeberle et al (2008) Swelling-activated Ca2+ channels trigger Ca2+ signals in Merkel cells. Nat Commun 3 e1750 PMID: 18454189
Hashiguchi (2017) Direct versus indirect actions of ghrelin on hypothalamic NPY neurons. PLoS One 12 e0184261 PMID: 28877214
Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. PLoS One 350 290 PMID: 24891452
Schöbel et al (2012) Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses. PLoS One 7 e48005 PMID: 23144843
ω-Conotoxin MVIIC 的评论
平均评分: 4.5 (基于 2 条评论。)
Have you used ω-Conotoxin MVIIC?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Suppression of a whole neuron response.
By
Anonymous on 06/21/2023
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Cerebellum
omega -Conotoxin MVIIC in combination with tetrodotoxin was used to clear stimulation artifact from whole-cell electrophysiological response of cerebellar granule cell. Top trace: control response; bottom trace: conotoxin (10 nM) + omega -Conotoxin MVIIC (1 microM) added to perfusion solution.
breast cancer cell viability by a cannabinoid receptor 2 agonist.
By
Anonymous on 03/15/2020
分析类型： In Vitro
种属： Human
细胞系/组织： MCF-7
We used all these compounds which were dissolved in DMSO and added to fresh culture media. Concentration reference paper PMID: 27186076
