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WAY 200070

Cat. No. 3366 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3366 has been discontinued.

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说明： Selective ERβ agonist
化学名： 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for WAY 200070

WAY 200070 is a selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Displays antianxiolytic and antidepressive effects in vivo.

技术数据 for WAY 200070

分子量 306.11
公式 C13H8BrNO3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 440122-66-7
PubChem ID 9861330
InChI Key IVFWABSHZFOMIG-UHFFFAOYSA-N
Smiles BrC1=C2C(N=C(C3=CC=C(O)C=C3)O2)=CC(O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for WAY 200070

参考文献是支持产品生物活性的出版物。

Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021 PMID: 15456246

Hughes et al (2008) WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology 54 1136 PMID: 18423777

Clipperton et al (2008) Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology 33 2362 PMID: 18004284

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关键词: WAY 200070, WAY 200070 supplier, Selective, ERβ, ERbeta, agonists, estrogen, receptors, WAY200070, Estrogen, and, Related, Receptors, 3366, Tocris Bioscience

4 篇 WAY 200070 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WAY 200070 的部分引用包括：

Cao et al (2012) Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat. J Pain 13 685 PMID: 22698981

Oberlander (2016) 17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females. J Neurosci 36 2677 PMID: 26937008

Sellers et al (2015) Rapid modulation of synaptogenesis and spinogenesis by 17β-OE in primary cortical neurons. Front Cell Neurosci 9 137 PMID: 25926772

Alonso-Magdalena et al (2013) Antidiabetic actions of an estrogen receptor β selective agonist. PLoS One 62 2015 PMID: 23349481

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Pathways for WAY 200070

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.