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Submit ReviewWB 4101 hydrochloride
Discontinued Product
0946 has been discontinued.
View all Adrenergic α<sub>1</sub> Receptors products.
说明： α1A antagonist
化学名： 2-(2,6-Dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane hydrochloride
纯度： ≥99% (HPLC)
生物活性 for WB 4101 hydrochloride
α1A-adrenergic selective antagonist.
技术数据 for WB 4101 hydrochloride
| 分子量 | 381.86 |
| 公式 | C19H23NO5.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 2170-58-3 |
| PubChem ID | 11957505 |
| InChI Key | KAHMEWANVDFFCQ-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC=CC(OC)=C1OCCNCC1COC2=C(O1)C=CC=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for WB 4101 hydrochloride
参考文献 for WB 4101 hydrochloride
参考文献是支持产品生物活性的出版物。
Green et al (1969) The synthesis and pharmacological properties of a series of 2-substituted aminomethyl-1,4-benzodioxanes. J.Med.Chem. 12 326 PMID: 5791620
Heible et al (1995) α and β-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428
Morrow and Creese (1986) Characterisation of α1-adrenergic receptor subtypes in rat brain: a re-evaluation of 3H-WB 4101 and 3H-prazosin binding. Mol.Pharmacol. 29 321 PMID: 3010073
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关键词: WB 4101 hydrochloride, WB 4101 hydrochloride supplier, α1A-adrenoceptor, alpha1A-adrenoceptor, α1a-adrenergic, alpha1a-adrenergic, antagonists, a1a-Adrenergic, a1a-adrenoceptors, Receptors, WB4101, hydrochloride, Adrenergic, Alpha-1, 0946, Tocris Bioscience
5 篇 WB 4101 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 WB 4101 hydrochloride 的部分引用包括：
O-Uchi et al (2008) Interaction of α1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. J Endocrinol 102 1378 PMID: 18467629
Crestani et al (2008) Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats. Br J Pharmacol 153 583 PMID: 18037912
Alves et al (2014) Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats. Circ Res 9 e83900 PMID: 24404141
Li et al (2018) Identification of WB4101, an α1-Adrenoceptor Antagonist, as a Sodium Channel Blocker. Mol Pharmacol 94 896 PMID: 29884692
Hott et al (2012) Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear. Br J Pharmacol 167 207 PMID: 22506532
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.