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WIN 18446

Cat. No. 4736 4 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： ALDH1A2 inhibitor
化学名： N,N'-1,8-Octanediylbis(2,2-dichloroacetamide)
说明书
引用文献 (4)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WIN 18446

WIN 18446 is an inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2) (IC50 = 0.3 μM). Inhibits the biosynthesis of retinoic acid from retinol in neonatal and adult murine testis.

技术数据 for WIN 18446

分子量 366.11
公式 C12H20Cl4N2O2
储存 Store at +4°C
CAS Number 1477-57-2
PubChem ID 15134
InChI Key FAOMZVDZARKPFJ-UHFFFAOYSA-N
Smiles ClC(Cl)C(NCCCCCCCCNC(C(Cl)Cl)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WIN 18446

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.61 100

制备储备液 for WIN 18446

以下数据基于产品分子量 366.11。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.73 mL 13.66 mL 27.31 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
10 mM 0.27 mL 1.37 mL 2.73 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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产品说明书 for WIN 18446

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for WIN 18446

参考文献是支持产品生物活性的出版物。

Amory et al (2011) Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J.Androl. 32 111 PMID: 20705791

Hogarth et al (2011) Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol.Reprod. 84 957 PMID: 21209416

If you know of a relevant reference for WIN 18446, please let us know.

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关键词: WIN 18446, WIN 18446 supplier, WIN18446, spermatogenesis, inhibitors, inhibits, aldehyde, dehydrogenases, ALDH1a2, Aldehyde, Dehydrogenase, 4736, Tocris Bioscience

4 篇 WIN 18446 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WIN 18446 的部分引用包括：

Martine et al (2017) Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis. Sci Rep 7 17759 PMID: 29259204

Barrionuevo et al (2016) Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration. Elife 5 PMID: 27328324

Ana-Maria et al (2022) Epithelial colonization by gut dendritic cells promotes their functional diversification. Immunity 55 129-144.e8 PMID: 34910930

Corinne et al (2020) PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment. Elife 9 PMID: 33047671

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WIN 18446 的评论

平均评分: 4 (Based on 1 Review.)

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Effectively inhibits human Aldh1a2.
By Anonymous on 09/13/2019
分析类型： In Vitro
种属： Human

This was used to inhibit recombinant Aldh1a2 activity in a titration curve.

Win-18446 showed an IC50 value at approximately 15 uM in a cell-free reaction assay. Was dissolved in DMSO to 100 mM with no solubility issues.

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