WIN 55,212-3 mesylate

Name: WIN 55,212-3 mesylate
Brand: Tocris Bioscience
SKU: 2327

Cat. No. 2327 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2327 has been discontinued.

View all Non-selective Cannabinoids products.

说明： CB₂ antagonist/CB₁ partial inverse agonist; enantiomer of WIN 55,212-2 (Cat. No. 1038)

别名： (S)-(-)-WIN 55,212

化学名： [(3S)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone monomethanesulfonate

纯度： ≥98% (HPLC)

说明书

引用文献 (2)

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for WIN 55,212-3 mesylate

Novel, low potency CB₂ receptor silent antagonist and CB₁ receptor partial inverse agonist. Competitively antagonizes effects of CP 55,940 (pA₂ = 6.1) and SR 144528 (pEC₅₀ = 5.3) at CB₂ receptors and acts as a partial inverse agonist at CB₁ receptors (pIC₅₀ = 5.5). Displays modest activity at human melatonin MT₁ and muscarinic M₄ receptors, but is selective over several other GPCRs.

R-enantiomer also available.

技术数据 for WIN 55,212-3 mesylate

分子量	522.61
公式	C₂₇H₂₆N₂O₃.CH₃SO₃H
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	131543-25-4
PubChem ID	11613341
InChI Key	FSGCSTPOPBJYSX-BDQAORGHSA-N
Smiles	CS(O)(=O)=O.CC1=C(C(=O)C2=CC=CC3=C2C=CC=C3)C2=CC=CC3=C2N1[C@@H](CN1CCOCC1)CO3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for WIN 55,212-3 mesylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for WIN 55,212-3 mesylate

参考文献是支持产品生物活性的出版物。

Savinainen et al (2005) Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB₂ receptor. Br.J.Pharmacol. 145 636 PMID: 15852035

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2 篇 WIN 55,212-3 mesylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WIN 55,212-3 mesylate 的部分引用包括：

Mereu et al (2003) Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release. Proc Natl Acad Sci U S A 100 4915 PMID: 12679519

Sousa et al (2011) Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory. Neuropsychopharmacology 36 472 PMID: 20927050