主页 / 药理学 / Ion Channels / Transient Receptor Potential Channels / TRPM Channels / TRPM Channel Agonists / WS 12

WS 12

Cat. No. 3040 2 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： TRPM8 agonist; cooling agent
化学名： (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WS 12

WS 12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM).

技术数据 for WS 12

分子量 289.41
公式 C18H27NO2
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 68489-09-8
PubChem ID 11266244
InChI Key HNSGVPAAXJJOPQ-XOKHGSTOSA-N
Smiles C[C@H](C)[C@H]1[C@H]([C@@](NC2=CC=C(OC)C=C2)=O)C[C@H](C)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WS 12

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 21.71 75

制备储备液 for WS 12

以下数据基于产品分子量 289.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.75 mM 4.61 mL 23.04 mL 46.07 mL
3.75 mM 0.92 mL 4.61 mL 9.21 mL
7.5 mM 0.46 mL 2.3 mL 4.61 mL
37.5 mM 0.09 mL 0.46 mL 0.92 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for WS 12

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for WS 12

参考文献是支持产品生物活性的出版物。

Beck et al (2007) Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium 41 285 PMID: 16949669

Bodding et al (2007) Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium 42 618 PMID: 17517434

If you know of a relevant reference for WS 12, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 TRPM Channel Agonists

关键词: WS 12, WS 12 supplier, TRPM8, agonists, cooling, agent, Channels, Transient, Receptor, Potential, WS12, TRPM, 3040, Tocris Bioscience

2 篇 WS 12 的引用文献

引用文献是使用了 Tocris 产品的出版物。 WS 12 的部分引用包括：

Morgan et al (2015) Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Biosci Rep 35 PMID: 26330615

Liu et al (2013) TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Pain 154 2169 PMID: 23820004

您是否知道使用了 Tocris WS 12 的优秀论文？ 请告知我们.

WS 12 的评论

平均评分: 5 (基于 2 条评论。)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used WS 12?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Activation of TRPM8 currents.
By Anonymous on 01/18/2018
分析类型： In Vitro
种属： Rat

WS12 was used to activate TRPM8 currents in dorsal root ganglia neurons through whole cell mode patch clamp.

WS12 as selective TRPM8 agonist and better than menthol..
By Hiteshkumar Soni on 01/10/2018
分析类型： In Vivo
种属： Mouse
细胞系/组织： Mouse Mesenteric artery

TRP Ion channel, TRPM8 agonist in in vivo experiments in mouse and in vitro tissue, especially Mouse Mesenteric artery to check change in arterial diameter.

review image