Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewWWL 113
说明： Ces3 and Ces1f inhibitor
化学名： 4'-[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1'-biphenyl]-4-carboxylic acid ethyl ester
纯度： ≥99% (HPLC)
生物活性 for WWL 113
WWL 113 is a carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.
技术数据 for WWL 113
| 分子量 | 466.53 |
| 公式 | C29H26N2O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 947669-86-5 |
| PubChem ID | 17759482 |
| InChI Key | AKIIPHDGVCFVCC-UHFFFAOYSA-N |
| Smiles | CN(C(OC3=CC=C(C4=CC=C(C(OCC)=O)C=C4)C=C3)=O)CC1=CC=CC(C2=CC=NC=C2)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for WWL 113
参考文献 for WWL 113
参考文献是支持产品生物活性的出版物。
Dominguez et al (2014) Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat.Chem.Biol. 10 113 PMID: 24362705
按产品操作查看相关产品
关键词: WWL 113, WWL 113 supplier, WWL113, carboxyesterases, Ces3, ces1d, cesif, ABHD6, hydrolases, serine, lipids, metabolism, obesity, diabetes, Other, Hydrolases, Lipid, Metabolism, 5259, Tocris Bioscience
1 篇 WWL 113 的引用文献
引用文献是使用了 Tocris 产品的出版物。 WWL 113 的部分引用包括：
Patra et al (2018) Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol 20 811 PMID: 29941929
WWL 113 的评论
目前没有该产品的评论。 Be the first to review WWL 113 and earn rewards!
Have you used WWL 113?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image