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Submit ReviewWWL 70
说明： Potent ABHD6 inhibitor
化学名： N-Methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl carbamic acid ester
纯度： ≥98% (HPLC)
生物活性 for WWL 70
WWL 70 is a potent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM), an enzyme which catalyzes the hydrolysis of 2-arachidonylglycerol (Cat. No. 1298).
技术数据 for WWL 70
| 分子量 | 437.49 |
| 公式 | C27H23N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 947669-91-2 |
| PubChem ID | 17759121 |
| InChI Key | QTWNORFUQILKJL-UHFFFAOYSA-N |
| Smiles | O=C(N(C)CC2=CC(C4=CC=NC=C4)=CC=C2)OC1=CC=C(C3=CC=C(C(N)=O)C=C3)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for WWL 70
参考文献 for WWL 70
参考文献是支持产品生物活性的出版物。
Blankman et al (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonylglycerol. Chem.Biol. 14 1347 PMID: 18096503
Li et al (2007) A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J.Am.Chem.Soc. 129 9594 PMID: 17629278
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关键词: WWL 70, WWL 70 supplier, WWL70, potent, ABHD6, inhibitors, αβ-hydrolase, domain, 6, alphabeta-hydrolase, endocannabinoids, 2-arachidonylglycerol, hydrolysis, inhibits, Other, Hydrolases, Cannabinoids, 3252, Tocris Bioscience
1 篇 WWL 70 的引用文献
引用文献是使用了 Tocris 产品的出版物。 WWL 70 的部分引用包括：
Tchantchou and Zhang (2013) Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury. J Neurotrauma 30 565 PMID: 23151067
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