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Submit ReviewWY 45233 succinate
说明： 5-HT and NA reuptake inhibitor (SNRI)
别名： Desvenlafaxine
化学名： 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol succinate
纯度： ≥99% (HPLC)
生物活性 for WY 45233 succinate
WY 45233 succinate is a serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Inhibits [3H]5-HT and [3H]NE uptake (IC50 values are 47.3 and 531.3 nM). Salt form of the major active metabolite of venlafaxine (Cat. No. 2917).
许可信息
Sold for research purposes under agreement from Pfizer Inc.
技术数据 for WY 45233 succinate
| 分子量 | 381.46 |
| 公式 | C16H25NO2.C4H6O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 448904-47-0 |
| PubChem ID | 9800068 |
| InChI Key | ORUUBRMVQCKYHB-UHFFFAOYSA-N |
| Smiles | OC1(C(CN(C)C)C2=CC=C(O)C=C2)CCCCC1.O=C(CCC(O)=O)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for WY 45233 succinate
参考文献 for WY 45233 succinate
参考文献是支持产品生物活性的出版物。
Alfinito et al (2006) Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and NE reuptake inhibitor desvenlaf. succinate in ovariectomized Sprague-Dawley rats. Brain Res. 1098 71 PMID: 16764833
Deecher et al (2006) Desvenlafaxine succinate: a new serotonin and NE reuptake inhibitor. J.Pharmacol.Exp.Ther. 318 657 PMID: 16675639
Mason et al (2007) Desvenlafaxine succinate identifies novel antagonist binding determinants in the human NE transporter. J.Pharmacol.Exp.Ther. 323 720 PMID: 17673606
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.