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Submit ReviewWZ 811
说明： Potent CXCR4 antagonist
化学名： N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
纯度： ≥99% (HPLC)
生物活性 for WZ 811
WZ 811 is a potent chemokine receptor type 4 (CXCR4) antagonist (EC50 = 0.3 nM). Inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cAMP in vitro (EC50 = 1.2 nM).
技术数据 for WZ 811
| 分子量 | 290.36 |
| 公式 | C18H18N4 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 55778-02-4 |
| PubChem ID | 11565518 |
| InChI Key | KBVFRXIGQQRMEF-UHFFFAOYSA-N |
| Smiles | C1(CNC3=NC=CC=C3)=CC=C(CNC2=NC=CC=C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for WZ 811
参考文献 for WZ 811
参考文献是支持产品生物活性的出版物。
Zhan et al (2007) Discovery of small molecule CXCR4 antagonists. J.Med.Chem. 50 5655 PMID: 17958344
Reyes et al (2002) Pyridinium N-(2'-azinyl)aminides: regioselective synthesis of N-(2-pyridyl) substituted polyamines. Chem.Inform. 34
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关键词: WZ 811, WZ 811 supplier, WZ811, chemokine, receptors, receptor, type, 4, antagonists, CXCR4, Chemokine, CXC, Receptors, 3951, Tocris Bioscience
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