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Submit ReviewXAP 044
说明： Potent and selective mGlu7 antagonist
化学名： 7-Hydroxy-3-(4-iodophenoxy)-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
生物活性 for XAP 044
XAP 044 is a potent and selective mGlu7 antagonist (IC50 = 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7 deficient mice. Exhibits novel activity by binding to the mGlu7 Venus flytrap domain (VFTD). Exhibits anti-anxiety effects in rodent models. Brain penetrant.
技术数据 for XAP 044
| 分子量 | 380.13 |
| 公式 | C15H9IO4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 196928-50-4 |
| PubChem ID | 5428913 |
| InChI Key | XXZKJJYWINSUMJ-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(C(C(OC3=CC=C(I)C=C3)=CO2)=O)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for XAP 044
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 38.01 | 100 | |
| ethanol | 7.6 | 20 |
制备储备液 for XAP 044
以下数据基于产品分子量 380.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.63 mL | 13.15 mL | 26.31 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 10 mM | 0.26 mL | 1.32 mL | 2.63 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.53 mL |
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产品说明书 for XAP 044
参考文献 for XAP 044
参考文献是支持产品生物活性的出版物。
Gee et al (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J.Biol.Chem. 289 10975 PMID: 24596089
If you know of a relevant reference for XAP 044, please let us know.
关键词: XAP 044, XAP 044 supplier, XAP044, potent, specific, mGlu7, antagonists, glutamate, metabotropic, group, III, receptors, venus, flytrap, domain, VFTD, anti-anxiety, Brain, penetrant, Glutamate, (Metabotropic), Group, Receptors, 5248, Tocris Bioscience
XAP 044 的评论
平均评分: 4 (Based on 1 Review.)
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XAP044 successfully antagonize the effect of L-AP4- stimulated mGlu7 receptors.
By
Anonymous on 01/05/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HEK293 cells
We have studied the cross-talk between mGlu7 and alpha1-adrenergic receptor in recombinant HEK293 cells and XAP 044 was successfully used to antagonize the effect of L-AP4. Briefly, after transfection, we measured the modulation of L-AP4, the mGlu7 receptor agonist on phenylephrine-induced stimulation of inositol phosphates formation. The effect of L-AP4 was antagonised by XAP044 (at 10 and 100 micromolar)
该领域的文献
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