XCT 790

Cat. No. 3928 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective ERRα inverse agonist

化学名： 3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide

纯度： ≥99% (HPLC)

引用文献 (4)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for XCT 790

XCT 790 is a selective ERRα inverse agonist (IC₅₀ = ~400 nM). Displays no antagonist activity at ERRγ or ERα at concentrations below 10 μM. Interferes with PPARγ coactivator-1α (PGC-1α)/ERRα-dependent signaling: inhibits PGC-1α induction of ERRα and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα in numerous cell lines.

技术数据 for XCT 790

分子量	596.42
公式	C₂₃H₁₃F₉N₄O₃S
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	725247-18-7
PubChem ID	6918788
InChI Key	HQFNFOOGGLSBBT-AWNIVKPZSA-N
Smiles	O=C(NC3=NN=C(C(F)(F)F)S3)/C(C#N)=C/C(C=C2OC)=CC=C2OCC1=C(C(F)(F)F)C=C(C(F)(F)F)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for XCT 790

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	5.96	10 温和加热

制备储备液 for XCT 790

以下数据基于产品分子量 596.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	16.77 mL	83.83 mL	167.67 mL
0.5 mM	3.35 mL	16.77 mL	33.53 mL
1 mM	1.68 mL	8.38 mL	16.77 mL
5 mM	0.34 mL	1.68 mL	3.35 mL

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产品说明书 for XCT 790

分析证书/产品说明书

化学品安全技术说明书

参考文献 for XCT 790

参考文献是支持产品生物活性的出版物。

Lanvin et al (2007) Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-α inverse agonist XCT790. J.Biol.Chem. 282 28328 PMID: 17631492

Kong et al (2009) Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase. Mol.Pharmacol. 76 854 PMID: 19602572

Willy et al (2004) Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor alpha (ERRα) ligand. Proc.Natl.Acad.Sci.USA 101 8912

Theodoris et al (2021) Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease. Science. 371 PMID: 33303684

If you know of a relevant reference for XCT 790, please let us know.

按标靶查看相关产品

Estrogen and Related Receptors

关键词: XCT 790, XCT 790 supplier, XCT790, ERRalpha, ERRa, ERRα, antagonists, inverse, agonists, PPARγ, PPARg, PPARgamma, coactivator-1α, coactivator-1alpha, coactivator-1a, PGC-1α, PGC-1alpha, PGC-1a, signaling, signalling, Estrogen, and, Related, Receptors, 3928, Tocris Bioscience

4 篇 XCT 790 的引用文献

引用文献是使用了 Tocris 产品的出版物。 XCT 790 的部分引用包括：

Teng et al (2014) Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals. Mol Cancer 444 177 PMID: 24457025

Núria et al (2021) The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation. Cell Metab 33 379-394.e8 PMID: 33301705

Michael P et al (2015) Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC). Oncotarget 6 25135-48 PMID: 26312764

Hwang et al (2014) Estrogen-related receptor α is required for efficient human cytomegalovirus replication. Proc Natl Acad Sci U S A 111 E5706 PMID: 25512541

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Pathways for XCT 790

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.