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Submit ReviewXEN 445
说明： Selective endothelial lipase inhibitor; orally bioavailable
化学名： 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid
纯度： ≥98% (HPLC)
生物活性 for XEN 445
XEN 445 is a selective endothelial lipase (EL) inhibitor (IC50 = 237 nM for human EL). Exhibits >20-fold selectivity for EL over lipoprotein lipase (LPL) and hepatic lipase (HL). Increases high density lipoprotein cholesterol (HDLc) plasma levels in mice. Orally bioavailable.
技术数据 for XEN 445
| 分子量 | 366.33 |
| 公式 | C18H17F3N2O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1515856-92-4 |
| PubChem ID | 72736173 |
| InChI Key | NBGRERFNOKZQLO-AWEZNQCLSA-N |
| Smiles | OC(C1=C(N2CC[C@H](OCC3=CC=CC=N3)C2)C=CC(C(F)(F)F)=C1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for XEN 445
参考文献 for XEN 445
参考文献是支持产品生物活性的出版物。
Sun et al (2013) Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg.Med.Chem. 21 7724 PMID: 24211162
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关键词: XEN 445, XEN 445 supplier, XEN445, Selective, endothelial, lipase, EL, inhibitors, inhibits, orally, bioavailable, Lipases, 5839, Tocris Bioscience
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