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XR 9051 HCl

Cat. No. 2944 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2944 has been discontinued.

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说明： Potent modulator of P-gp-mediated MDR
化学名： N-[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-3-[(Z)-[(5Z)-4-methyl-3,6-dioxo-5-(phenylmethylene)piperazinylidene]methyl]benzamide hydrochloride
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for XR 9051 HCl

Potent modulator of P-glycoprotein-mediated multidrug resistance (MDR) that inhibits the binding of cytotoxics to P-glycoprotein (EC50 = 134 nM). Reverses resistance to a variety of cytotoxic drugs (including doxorubicin, etoposide and vincristine) in several murine and human P-gp-overexpressing cell lines. Orally active.

技术数据 for XR 9051 HCl

分子量 679.2
公式 C39H38N4O5.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 180422-22-4
Smiles O=C(C3=CC=CC(/C=C5\NC(/C(N(C)C5=O)=C/C4=CC=CC=C4)=O)=C3)NC(C=C2)=CC=C2CCN1CC(C=C(OC)C(OC)=C6)=C6CC1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for XR 9051 HCl

参考文献是支持产品生物活性的出版物。

Dale et al (1998) Reversal of P-glycoprotein-mediated multidrug resistance by XR9051, a novel diketopiperazine derivative. Br.J.Cancer 78 885 PMID: 9764579

Mistry et al (1999) In vivo efficacy of XR9051, a potent modulator of P-glycoprotein mediated multidrug resistance. Br.J.Cancer 79 1672 PMID: 10206276

Martin et al (2000) Communication between multidrug binding sites on P-glycoprotein. Mol.Pharmacol. 58 624 PMID: 10953057

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关键词: XR 9051 HCl, XR 9051 HCl supplier, Potent, modulators, P-gp-mediated, MDR, P-glycoprotein, Resistance, Protein, Multidrug, Transporters, XR9051, ABCB1, 2944, Tocris Bioscience

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