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Y 134

Cat. No. 2676 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective estrogen receptor modulator (SERM), selective for ERα
化学名： [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[4-(1-methylethyl)-1-piperazinyl]phenyl]methanone
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Y 134

Y 134 is a selective estrogen receptor modulator (SERM) that displays selectivity for ERα over ERβ (Ki values are 0.09 and 11.31 nM respectively) and no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Acts as an agonist in the bone and antagonist in reproductive tissue. Suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells.

技术数据 for Y 134

分子量 472.6
公式 C28H28N2O3S
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 849662-80-2
PubChem ID 11784736
InChI Key LQEOPHGPHCWOAC-UHFFFAOYSA-N
Smiles CC(C)N1CCN(CC1)C1=CC=C(C=C1)C(=O)C1=C(SC2=CC(O)=CC=C12)C1=CC=C(O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Y 134

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 47.26 100
ethanol 47.26 100

制备储备液 for Y 134

以下数据基于产品分子量 472.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.12 mL 10.58 mL 21.16 mL
5 mM 0.42 mL 2.12 mL 4.23 mL
10 mM 0.21 mL 1.06 mL 2.12 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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参考文献 for Y 134

参考文献是支持产品生物活性的出版物。

Yang et al (2005) Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor α and their bioactivities in vivo. Bioorg.Med.Chem.Lett. 15 1505 PMID: 15713417

Ning et al (2007) Biological activities of a novel selective oestrogen receptor modulator derived from ralox. (Y134). Br.J.Pharmacol. 150 19 PMID: 17115070

If you know of a relevant reference for Y 134, please let us know.

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关键词: Y 134, Y 134 supplier, Selective, estrogen, receptor, modulators, SERM, selective, Erα, Eralpha, ERR, Estrogen, Receptors, Y134, and, Related, 2676, Tocris Bioscience

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Pathways for Y 134

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.