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Submit ReviewY-27632 dihydrochloride
说明： Y-27632 synthesized to cGMP guidelines
化学名： trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride
纯度： ≥99%
生物活性 for Y-27632 dihydrochloride
Y-27632 dihydrochloride is a Y-27632 synthesized to cGMP guidelines. Suitable for use as an ancillary reagent in the further manufacturing of cell therapies.
For more information about how Y-27632 may be used, please see our protocols: Transdifferentiating Fibroblasts into Neurons, Converting Fibroblasts into Cardiomyocytes (9C Cocktail), Accelerated Induction of Cortical Neurons from hiPSCs, Human iPSC-derived Myoblasts.
Research use only Y-27632 also available.
Current Good Manufacturing Practice (cGMP) is a harmonized set of guidelines that when implemented will ensure safe, reliable, consistent and quality-assured products. The Tocris range of cGMP small molecules is manufactured following relevant sections of ICH Q7 guidelines. Our highly skilled team has full control over the cGMP process, meaning we can ensure: a quality-assured manufacturing system, batch-to-batch consistency, consistent supply, traceability from starting material to final product, and animal-free production. Find out more about the Tocris range of cGMP compounds.
技术数据 for Y-27632 dihydrochloride
| 分子量 | 320.26 |
| 公式 | C14H21N3O.2HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% |
| CAS Number | 129830-38-2 |
| InChI Key | IDDDVXIUIXWAGJ-LJDSMOQUSA-N |
| Smiles | N[C@H](C)[C@@]1([H])CC[C@H](C(NC2=CC=NC=C2)=O)CC1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
This product is intended for research use or further manufacturing only.
产品说明书 for Y-27632 dihydrochloride
分析证书目前不在网上提供。
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参考文献 for Y-27632 dihydrochloride
参考文献是支持产品生物活性的出版物。
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关键词: Y-27632 dihydrochloride, Y-27632 dihydrochloride supplier, cGMP, Good, Manufacturing, Practice, Process, Selective, p160ROCK, inhibitors, inhibits, Rho-Kinase, Rho-Associated, Coiled-Coil, Kinases, ROCK, ROK, stem, cells, organoids, GMP, Small, Molecules, TB1254-GMP, Tocris Bioscience
3 篇 Y-27632 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Y-27632 dihydrochloride 的部分引用包括：
Gantner et al (2020) An optimized protocol for the generation of midbrain dopamine neurons under defined conditions. STAR Protoc. 1 100065 PMID: 33111103
Ma et al (2021) Generation of an iPSC line (SMCPGi001-A) from a patient with Bain type X-linked mental retardation syndrome carrying HNRNPH2 gene mutation. Stem Cell Res. 57 102571 PMID: 34763229
Guo et al (2021) Establishment of an induced pluripotent stem cell line (ZJSHi001-A) from a patient with epileptic encephalopathy carrying KCNB1 Glu330Asp mutation. Stem Cell Res. 52 102224 PMID: 33607466
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Y-27632 dihydrochloride 实验方案
The following protocols feature additional information for the use of Y-27632 dihydrochloride (Cat. No. TB1254-GMP).
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
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Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.