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说明： SIRT1 activator
化学名： B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid
纯度： ≥98% (HPLC)
生物活性 for YK 3-237
YK 3-237 is a SIRT1 activator. Inhibits proliferation of breast cancer cell lines expressing mutant p53. Induces G2/M cell cycle arrest and apoptosis in triple negative breast cancer cells (TNBCs) in vitro.
技术数据 for YK 3-237
| 分子量 | 372.18 |
| 公式 | C19H21BO7 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1215281-19-8 |
| PubChem ID | 24881094 |
| InChI Key | AKNGHUAJAODDJA-FNORWQNLSA-N |
| Smiles | O=C(/C=C/C1=CC=C(OC)C(B(O)O)=C1)C2=CC(OC)=C(OC)C(OC)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for YK 3-237
参考文献 for YK 3-237
参考文献是支持产品生物活性的出版物。
Yi et al (2013) Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells. Oncotarget 4 984 PMID: 23846322
Ponnusamy et al (2015) Activation of sirtuin-1 promotes renal fibroblast activation and aggravates renal fibrogenesis. J.Pharmacol.Exp.Ther 354 142 PMID: 26022003
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关键词: YK 3-237, YK 3-237 supplier, YK3-237, SIRT1, sirtuins, activators, activates, deacetylases, antiproliferative, Class, III, HDACs, (Sirtuins), 5667, Tocris Bioscience
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