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YKL 5-124

Cat. No. 7157 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective CDK7 inhibitor; induces cell cycle arrest
化学名： N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
纯度： ≥95% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for YKL 5-124

YKL-5-124 is a potent and selective CDK7/Mat1/CycH and cyclin dependent kinase (CDK7) inhibitor (IC50 values = 9.7 nM and 53.5 nM, respectively). YKL-5-124 shows 100-fold selectivity over CDK9 and CDK2. YKL-5-124 induces cell cycle arrest at the G1/S transition, inhibits E2F-driven gene expression and inhibits CDK1 and CDK3 T-loop phosphorylation.

许可信息

Sold under license from Dana-Farber Cancer Institute.

技术数据 for YKL 5-124

分子量 515.62
公式 C28H33N7O3
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 1957203-01-8
PubChem ID 121443990
InChI Key KPABJHHKKJIDGX-JOCHJYFZSA-N
Smiles CN(C[C@H](C1=CC=CC=C1)NC(N2CC3=C(C2(C)C)NN=C3NC(C4=CC=C(C=C4)NC(C=C)=O)=O)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for YKL 5-124

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.31 20
ethanol 10.31 20

制备储备液 for YKL 5-124

以下数据基于产品分子量 515.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 9.7 mL 48.49 mL 96.97 mL
1 mM 1.94 mL 9.7 mL 19.39 mL
2 mM 0.97 mL 4.85 mL 9.7 mL
10 mM 0.19 mL 0.97 mL 1.94 mL

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参考文献 for YKL 5-124

参考文献是支持产品生物活性的出版物。

Olson et al (2019) Development of a selective CDK7 covalent inhibitor reveals predominant cell-cycle phenotype. Cell Chem.Biol. 26 792 PMID: 30905681

If you know of a relevant reference for YKL 5-124, please let us know.

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关键词: YKL 5-124, YKL 5-124 supplier, YKL5124, CDK7, potent, selective, inhibitors, inhibits, cell, cycle, cyclin, dependent, kinases, Cell, Cycle, Inhibitors, Transcriptional, CDKs, 7157, Tocris Bioscience

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