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Submit ReviewYM 230888
Discontinued Product
2986 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
说明： Selective mGlu1 antagonist
化学名： 4-(Cycloheptylamino)-N-[[(2R)-tetrahydro-2-furanyl]methyl]-thieno[2,3-d]pyrimidine-6-methanamine
纯度： ≥99% (HPLC)
生物活性 for YM 230888
Selective mGlu1 antagonist (Ki = 13 nM). Inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells (IC50 = 13 nM). Displays antinociceptive and analgesic effects in vitro; exhibits no significant sedative effect on locomotor activity.
许可信息
Sold with the permission of Astellas Pharma Inc.
技术数据 for YM 230888
| 分子量 | 360.52 |
| 公式 | C19H28N4OS |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 446257-23-4 |
| PubChem ID | 11682007 |
| InChI Key | SASNRPJKZVJWQW-OAHLLOKOSA-N |
| Smiles | C1(NC4CCCCCC4)=C(C=C(CNC[C@H]3CCCO3)S2)C2=NC=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for YM 230888
参考文献 for YM 230888
参考文献是支持产品生物活性的出版物。
Kohara et al (2007) Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models. Eur.J.Pharmacol. 571 8 PMID: 17597604
Satow et al (2008) Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective allost J.Pharmacol.Exp.Ther. 326 577 PMID: 18487514
关键词: YM 230888, YM 230888 supplier, YM230888, mGlu1, metabotropic, glutamate, receptors, group, I, 1, antagonist, antagonists, mGlu, selective, Glutamate, (Metabotropic), Group, Receptors, 2986, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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