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Submit ReviewYM 26734
说明： Secretory phospholipase A2 (sPLA2) inhibitor
化学名： 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone
纯度： ≥95% (HPLC)
生物活性 for YM 26734
YM 26734 is a competitive inhibitor of secretory phospholipase A2 (sPLA2) that exhibits a broad inhibitory profile to several sPLA2s (IC50 values are 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.
技术数据 for YM 26734
| 分子量 | 730.97 |
| 公式 | C45H62O8 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 144337-18-8 |
| PubChem ID | 9853400 |
| InChI Key | CEJAYJCUSZHYDS-UHFFFAOYSA-N |
| Smiles | OC1=C(C2CC(C4=CC=C(O)C=C4)OC3=C2C=CC(O)=C3)C(O)=C(C(CCCCCCCCCCC)=O)C(O)=C1C(CCCCCCCCCCC)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for YM 26734
参考文献 for YM 26734
参考文献是支持产品生物活性的出版物。
Miyake et al (1993) Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carregeenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2. Br.J.Pharmacol. 110 447 PMID: 8220906
Miyake et al (1994) Exogenous group II phospholipase A2 prostaglandin E2 production in mouse peritoneal macrophages. Eur.J.Pharmacol. 253 155 PMID: 8013541
Hamaguchi et al (2003) Induction of distinct sets of secretory phospholipase A2 in rodents during inflammation. Biochim.Biophys.Acta 1635 37 PMID: 14642775
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关键词: YM 26734, YM 26734 supplier, Secretory, phospholipases, A2, sPLA2, inhibitors, inhibits, Esterases, YM26734, Phospholipases, 2522, Tocris Bioscience
2 篇 YM 26734 的引用文献
引用文献是使用了 Tocris 产品的出版物。 YM 26734 的部分引用包括：
Bianca et al (2010) Hydrogen sulphide induces mouse paw oedema through activation of phospholipase A2. Front Mol Neurosci 161 1835 PMID: 20825409
Pernet et al (2014) Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun 5 5105 PMID: 25290234
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