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说明： Potent aromatase (CYP19) inhibitor
化学名： 4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]benzonitrile
纯度： ≥99% (HPLC)
生物活性 for YM 511
YM 511 is an orally active, potent aromatase (CYP19) inhibitor (IC50 values are 0.4 and 0.12 nM at rat ovary and human placenta cells respectively) that only weakly inhibits the synthesis of other steroid hormones. Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC50 = 0.13 nM).
许可信息
(Sold with the permission of Astellas Pharma Inc.)
技术数据 for YM 511
| 分子量 | 354.2 |
| 公式 | C16H12BrN5 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 148869-05-0 |
| PubChem ID | 177865 |
| InChI Key | GGPPBTSXFROGAE-UHFFFAOYSA-N |
| Smiles | BrC(C=C3)=CC=C3CN(N2C=NN=C2)C1=CC=C(C#N)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for YM 511
参考文献 for YM 511
参考文献是支持产品生物活性的出版物。
Okada et al (1996) Studies on aromatase inhibitors I. Synthesis and biological evaulation of 4-amino-4H-1,2,4-triaole derivatives. Chem.Pharm.Bull. 44 1871 PMID: 8904814
Kudoh et al (1995) The potent and selective inhibiton of estrogen production by non-steroidal aromatase inhibitor, YM511. J.Steroid Biochem.Molec.Biol. 54 265
Kudoh et al (1996) Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell. J.Steroid Biochem.Molec.Biol. 58 189
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