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Submit ReviewYM 90K hydrochloride
说明： Selective AMPA antagonist
化学名： 1,4-Dihydro-6-(1H-imidazol-1-yl)-7-nitro-2,3-quinoxalinedione hydrochloride
纯度： ≥99% (HPLC)
生物活性 for YM 90K hydrochloride
YM 90K hydrochloride is a selective AMPA receptor antagonist (Ki values are 84, 2200 and > 37000 nM for AMPA, kainate and NMDA receptors respectively). Neuroprotective; delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration.
许可信息
Sold with the permission of Astellas Pharma Inc.
技术数据 for YM 90K hydrochloride
| 分子量 | 309.67 |
| 公式 | C11H7N5O4.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 154164-30-4 |
| PubChem ID | 5486547 |
| InChI Key | UMLFDVOHVJPDIZ-UHFFFAOYSA-N |
| Smiles | O=C(N2)C(NC1=C2C=C(N3C=NC=C3)C([N+]([O-])=O)=C1)=O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for YM 90K hydrochloride
参考文献 for YM 90K hydrochloride
参考文献是支持产品生物活性的出版物。
Ohmori et al (1994) 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor. J.Med.Chem. 37 467 PMID: 8120865
Umemura et al (1997) Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia. Brain Res. 773 61 PMID: 9409705
Nakano et al (2001) A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of N-acetylaspartate in the hippocampal CA1 area after transient unilateral forebrain ischemia in gerbils. Life Sci. 69 1983 PMID: 11589513
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关键词: YM 90K hydrochloride, YM 90K hydrochloride supplier, Selective, AMPA, antagonists, Glutamate, Receptors, iGluR, Ionotropic, YM90K, hydrochloride, 2701, Tocris Bioscience
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