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Yoda 2

Cat. No. 8051 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Piezo1 channel activator
化学名： Potassium 4-(5-((2,6-dichlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)benzoate
纯度： ≥97% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Yoda 2

Yoda 2 is a selective Piezo1 channel activator (EC50 values are 150 nM and 1.14 μM in mPiezo1 and HUVEC cells respectively). Increases Ca2+ signaling 2.8 fold in hPIEZO-TREx and 1.2 fold in mPIEZO1-TREx, compared to Yoda 1 (Cat. No. 5586). Induces concentration-dependent relaxation of mouse portal vein (EC50 = 1.2 μM). Suitable for use in vivo and in vitro.

技术数据 for Yoda 2

分子量 435.38
公式 C16H9Cl2N2O2S2K
储存 Store at -20°C
纯度 ≥97% (HPLC)
InChI Key OQEIWUHZUPFUQU-UHFFFAOYSA-M
Smiles O=C([O-])C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1.[K+]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Yoda 2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 43.54 100
DMSO 21.77 50

制备储备液 for Yoda 2

以下数据基于产品分子量 435.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.48 mL 22.97 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for Yoda 2

参考文献是支持产品生物活性的出版物。

Parsonage et al (2023) Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1. Br.J.Pharmacology 180 2039 PMID: 36457143

If you know of a relevant reference for Yoda 2, please let us know.

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关键词: Yoda 2, Yoda 2 supplier, Yoda2, piezo1, piezo, channel, channels, activator, activators, calcium, signaling, vein, relaxation, in, vivo, vitro, Piezo, Channels, 8051, Tocris Bioscience

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