Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewYohimbine hydrochloride
说明： Selective α2 antagonist
化学名： 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Yohimbine hydrochloride
Yohimbine hydrochloride is a α2-adrenoceptor antagonist (pKi values are 8.52, 8.00 and 9.17 for human α2A, α2B and α2C receptors respectively).
Diastereomer also available.
技术数据 for Yohimbine hydrochloride
| 分子量 | 390.91 |
| 公式 | C21H26N2O3.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 65-19-0 |
| PubChem ID | 6169 |
| InChI Key | PIPZGJSEDRMUAW-VJDCAHTMSA-N |
| Smiles | [H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@@]3([H])[C@]([C@@H]([C@@](OC)=O)[C@@H](O)CC3)([H])C2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Yohimbine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 7.82 | 20 温和加热 |
制备储备液 for Yohimbine hydrochloride
以下数据基于产品分子量 390.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.79 mL | 63.95 mL | 127.91 mL |
| 1 mM | 2.56 mL | 12.79 mL | 25.58 mL |
| 2 mM | 1.28 mL | 6.4 mL | 12.79 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Yohimbine hydrochloride
参考文献 for Yohimbine hydrochloride
参考文献是支持产品生物活性的出版物。
Doxey et al (1984) Comparison of the α-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine. Naunyn Schmiedebergs Arch.Pharmacol. 325 136 PMID: 6144048
Lalchandani et al (2002) Yohimbine dimers exhibiting selectivity for the human α2c-adrenoceptor subtype. J.Pharmacol.Exp.Ther. 303 979 PMID: 12438517
Redfern and Williams (1995) A re-evaluation of the role of α2-adrenoceptors in the anxiogenic effects of yohimbine, using the selective antagonist delequamine in the rat. Br.J.Pharmacol. 116 2081 PMID: 8640349
Goldberg and Robertson (1987) Yohimbine: a pharmacological probe for study of the α2-adrenoceptor. Pharmacol.Rev. 35 143
If you know of a relevant reference for Yohimbine hydrochloride, please let us know.
按产品操作查看相关产品
关键词: Yohimbine hydrochloride, Yohimbine hydrochloride supplier, Selective, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, antagonist, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Receptors, Adrenergic, Alpha-2, 1127, Tocris Bioscience
21 篇 Yohimbine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Yohimbine hydrochloride 的部分引用包括：
Soty et al (2015) A gut-brain neural circuit controlled by intestinal gluconeogenesis is crucial in metabolic health. Psychopharmacology (Berl) 4 106 PMID: 25685698
Phelps et al (2015) Psychopharmacological characterisation of the successive negative contrast effect in rats. Proc Natl Acad Sci U S A 232 2697 PMID: 25791190
André et al (2006) Enhancing functional production of G protein-coupled receptors in Pichia pastoris to levels required for structural studies via a single expression screen. Protein Sci 15 1115 PMID: 16597836
Yuen et al (2014) Synergistic regulation of glutamatergic transmission by serotonin and NE reuptake inhibitors in prefrontal cortical neurons. J Biol Chem 289 25177 PMID: 25056951
Delaney and Crane (2016) Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels. Sci Rep 6 19255 PMID: 26755335
Maupoil et al (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol 150 899 PMID: 17325650
Kastman et al (2016) Nucleus incertus Orexin2 receptors mediate alcohol seeking in rats Neuropharmacology 110 82 PMID: 27395787
Gazarini et al (2015) PTSD-like memory generated through enhanced noradrenergic activity is mitigated by a dual step pharmacological intervention targeting its reconsolidation. Int J Neuropsychopharmacol 18 PMID: 25539509
Dudek et al (2015) A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands guanf. and Yohimbine in Rats with Diet-Induced Obesity. PLoS One 10 e0141327 PMID: 26506439
Scardochio et al (2015) The Effects of Electrical and Optical Stimulation of Midbrain DArgic Neurons on Rat 50-kHz Ultrasonic Vocalizations. Front Behav Neurosci 9 331 PMID: 26696851
Costello et al (2014) Comparison of the reinforcing properties of nicotine and cigarette smoke extract in rats. Neuropsychopharmacology 39 1843 PMID: 24513971
Ciccocioppo et al (2014) Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat. Neuropsychopharmacology 39 2601 PMID: 24863033
Drake et al (2014) The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input. J Physiol 592 3611 PMID: 24879873
Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691
Barnea et al (2008) The genetic design of signaling cascades to record receptor activation. Proc Natl Acad Sci U S A 105 64 PMID: 18165312
Corcoran et al (2014) Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. Mol Metab 34 51 PMID: 24381267
Mondal et al (2013) Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons. PLoS One 8 e60365 PMID: 23565235
Ryan et al (2013) Relaxin-3/RXFP3 system regulates alcohol-seeking. Proc Natl Acad Sci U S A 110 20789 PMID: 24297931
Marchese et al (2003) Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications. Br J Pharmacol 140 520 PMID: 12970091
Gozzi et al (2013) Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine. Neuropsychopharmacology 38 2120 PMID: 23736277
Hirschberg et al (2017) Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. Elife 6 PMID: 29027903
您是否知道使用了 Tocris Yohimbine hydrochloride 的优秀论文？ 请告知我们.
Yohimbine hydrochloride 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Yohimbine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Chronic yohimbine stress increases vulnerability to reinstatement of palatable food seeking.
By
Kevin Ball on 01/25/2019
分析类型： In Vivo
种属： Rat
To model chronic stress, rats were injected daily with yohimbine (0.0, 2.5, or 5.0 mg/kg; i.p.) during the first 7 days of extinction from palatable food self-administration. Injections were combined with SCH-23390 (0.0, 5.0, or 10.0 μg/kg; i.p.), a dopamine D1-like receptor antagonist. Rats were then tested for reinstatement of food seeking triggered by acute yohimbine (0.0, 1.0, or 2.0 mg/kg; i.p.) and pellet priming. Rats treated previously with chronic yohimbine displayed increased responding following acute yohimbine and pellet priming relative to non-chronically stressed rats under certain conditions. SCH-23390 combined with repeated yohimbine injections attenuated these effects.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.