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Submit ReviewZ-Cyclopentyl-AP4
Discontinued Product
3249 has been discontinued.
View all Glutamate (Metabotropic) Group III Receptors products.
说明： Group III mGlu agonist (mGlu4 > mGlu8 > mGlu7)
化学名： cis-(±)-1-Amino-3-phosphonocyclopentane carboxylic acid
纯度： ≥98% (HPLC)
生物活性 for Z-Cyclopentyl-AP4
Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist that exhibits higher potency at mGlu4 than mGlu8 (EC50 values are 49 and 124 μM respectively) with no activity at mGlu7. Selectively inhibits synaptic activity in the lateral perforant pathway (IC50 values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Conformationally restrained analog of L-AP4 (Cat No. 0103).
技术数据 for Z-Cyclopentyl-AP4
| 分子量 | 209.14 |
| 公式 | C6H12NO5P |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 103439-17-4 |
| PubChem ID | 56972223 |
| InChI Key | GLBQBTFFQHNHGC-RPBIHNRISA-N |
| Smiles | [H][C@@]1(CC[C@@](N)(C1)C(O)=O)P(O)(O)=O.[H][C@]1(CC[C@](N)(C1)C(O)=O)P(O)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Z-Cyclopentyl-AP4
参考文献 for Z-Cyclopentyl-AP4
参考文献是支持产品生物活性的出版物。
Crooks et al (1986) Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding. J.Med.Chem. 29 1988 PMID: 3020251
Ayala et al (2008) Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated. Neuropharmacology 54 804 PMID: 18255102
Jones et al (2008) Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract-piriform cortex synpase. Neuropharmacology 55 440 PMID: 18625254
关键词: Z-Cyclopentyl-AP4, Z-Cyclopentyl-AP4 supplier, Group, III, mGlur, agonists, mGlu4, mGluR4, mGlu8, mGluR8, Receptors, Glutamate, Metabotropic, (Metabotropic), 3249, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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