Zamifenacin fumarate

Name: Zamifenacin fumarate
Brand: Tocris Bioscience
SKU: 2579

Cat. No. 2579 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2579 has been discontinued.

View all M<sub>3</sub> Receptors products.

说明： Selective M₃ antagonist

别名： UK 76654

化学名： (3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidine fumarate

纯度： ≥99% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Zamifenacin fumarate

Selective M₃ muscarinic receptor antagonist (pK_i values are 8.52, 7.93, 7.90 and 7.78 for M₃, M₂, M₁ and M₄ receptors respectively). Displays higher affinity at ileal M₃ receptors (pK_i = 9.3) compared to oesophageal and tracheal M₃ receptors (pK_i values are 8.8 and 8.2 respectively). Inhibits gastrointestinal motility in vivo in the absence of cardiovascular effects.

技术数据 for Zamifenacin fumarate

分子量	531.6
公式	C₂₇H₂₉NO₃.C₄H₄O₄
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	127308-98-9
PubChem ID	20056967
InChI Key	PMHKTAIGYOVZEZ-ZHWJIHCSSA-N
Smiles	C1(CCN3C[C@H](OC(C5=CC=CC=C5)C4=CC=CC=C4)CCC3)=CC=C(OCO2)C2=C1.C(\C=C\C(O[H])=O)(O[H])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Zamifenacin fumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Zamifenacin fumarate

参考文献是支持产品生物活性的出版物。

Wallis (1995) Pre-clinical and clinical pharmacology of selective muscarinic M₃ receptor antagonists. Life Sci. 56 861 PMID: 10188786

Watson et al (1995) Characterization of the interaction of zamifenacin at muscarinic receptors in vitro. Eur.J.Pharmacol. 285 135 PMID: 8566131

Choppin (2002) Muscarinic receptors in isolated urinary bladder smooth muscle from different mouse strains. Br.J.Pharmacol. 137 522 PMID: 12359634

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关键词: Zamifenacin fumarate, Zamifenacin fumarate supplier, Selective, M3, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, UK76654, UK, 76654, 2579, Tocris Bioscience

篇 Zamifenacin fumarate 的引用文献

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