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Zanamivir

Cat. No. 7187 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent influenza virus neuraminidase inhibitor
化学名： 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galactonon-2-enonic acid-glycero-D-galactonon-2-enonic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Zanamivir

Zanamivir is an influenza viral neuraminidase inhibitor (IC50 values are 0.95 nM and 2.7 nM for influenza A and B, respectively). Inhibits neuraminidase, preventing the cleavage of sialic acid on the cell receptors, and release of the newly formed virions.

技术数据 for Zanamivir

分子量 332.31
公式 C12H20N4O7
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 139110-80-8
PubChem ID 60855
InChI Key ARAIBEBZBOPLMB-UFGQHTETSA-N
Smiles [H][C@]1(OC(=C[C@H](NC(N)=N)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)CO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Zanamivir

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 1.66 5

制备储备液 for Zanamivir

以下数据基于产品分子量 332.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 60.18 mL 300.92 mL 601.85 mL
0.25 mM 12.04 mL 60.18 mL 120.37 mL
0.5 mM 6.02 mL 30.09 mL 60.18 mL
2.5 mM 1.2 mL 6.02 mL 12.04 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Zanamivir

参考文献是支持产品生物活性的出版物。

Gubareva et al (2001) Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants. Antimicrob.Agents Chemother. 45 3403 PMID: 11709315

Elliott et al (2001) Zanamivir: from drug design to the clinic. Philos.Trans.R.Soc.Lond.B.Biol.Sci. 356 1885 PMID: 11779388

McKimm-Breschkin et al (2005) Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance. Treat Respir.Med. 4 107 PMID: 15813662

If you know of a relevant reference for Zanamivir, please let us know.

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关键词: Zanamivir, Zanamivir supplier, influenza, flu, viral, neuraminidases, inhibitors, inhibits, covid-19, covid19, Other, Hydrolases, COVID-19, Influenza, Viruses, 7187, Tocris Bioscience

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